- 9th - Wasei "JJ" Chikada announced he will release his next record "Cyberia Layer_4" around April, 2022. (source)
- 11th - Launch of Yoshitoshi ABe's Patreon account. (source)
- 29th - Released of the fan project lainTSX recreating Serial Experiments Lain PS1 game in English and playable on web browser (source)
- 24th - Wasei “JJ” Chikada launches his weekly music streaming show Club Cyberia Wired. Every Wednesday at 10 p.m. JST. (source)
- 20th - Release of the remix album Cyberia Layer:03 "After Hours" (source)
- 23rd - Release of the concept album Cyberia Layer:03 by Wasei “JJ” Chikada with new art by Yoshitoshi ABe (source)
- 10th - Messa Store is gathering together artists and designers to celebrate Serial Experiments Lain creating a variety of shirts, hats, and other accessories (source)
- 13th - Residents of Japan have the express permission to create derivative works of Serial Experiments Lain for non-commercial purpose until July 2028 as part of an "Open Source Project." (source)
- 14th - Release of the concept album Cyberia Layer_2 by Wasei “JJ” Chikada with new art by Yoshitoshi ABe (source)
- 6th - Serial Experiments Lain celebrates its 20 years!
- 1st - Serial Experiments Lain is now available on the streaming platform Crunchyroll for the United States and Canada (source)
- 28th - Launch of The TSUKI Project website preaching a Serial Experiments Lain-inspired conspiracy. (source)
- 20th - Release of the Serial Experiments Lain: Complete Series Anime in Blu-ray (source)
- 29th - Ryūtarō Nakamura, director of Serial Experiments Lain, died due to pancreatic cancer. (source)
- 10th - At the Sakura-Con, Yoshitoshi ABe reveals he's working on the spiritual sequel of Serial Experiments Lain, Despera with many of the same staffers with whom he created Lain (source)
- 6th - Serial Experiments Lain celebrates its 10 years!